Dana A. Baum

My Research

Postdoctoral Work

I am currently pursuing my postdoc work in the lab of Dr. Scott Silverman at the University of Illinois at Urbana-Champaign. I am working with catalytic DNA, or deoxyribozymes. Yes, DNA can do more than just store genetic information! It's a fascinating area of research and we are finding new things all the time! For more on the work going on in the lab, check out the lab website. It is updated regularly!

2/8/08 - My time at Illinois is starting to wind down! I will be moving on to a faculty position in the fall! More on that once I officially start!

• Baum, D. A. & Silverman, S. K. (2008) "Deoxyribozymes: Useful DNA Catalysts In Vitro and In Vivo", submitted for publication (invited review).
  
  
• Pradeepkumar, P. I., Hoebartner, C., Baum, D. A. & Silverman, S. K. (2008) "DNA-Catalyzed Formation of Nucleopeptide Linkages" Angew. Chem. Int. Ed. 47, Early View.
  
  
• Patel, M. P., Baum, D. A. & Silverman, S. K. (2008) "Improvement of DNA Adenylation Using T4 DNA Ligase with a Template Strand and a Strategically Mismatched Acceptor Strand" Bioorg. Chem 36, in press.
  
  
• Baum, D. A. & Silverman, S. K. (2007) "Deoxyribozyme-Catalyzed Labeling of RNA" Angew. Chem. Int. Ed. 46, 3502.
  
  

Graduate Work

I received my Ph.D. in August 2005 from the Department of Chemistry at the University of Kentucky. I worked in the lab of Dr. Stephen Testa. The focus of my dissertation research was catalytic RNA. My dissertation is available online through the University of Kentucky Electronic Theses and Dissertations website.

My Publications as a Graduate Student

• Baum, D. A. & Testa, S. M. (2005) "In Vivo Excision of a Single Targeted Nucleotide from an mRNA by a Trans Excision-Splicing Ribozyme" RNA 11, 897-905.
  
  
• Alexander, R. C., Baum, D. A., & Testa, S. M. (2005) "5' Transcript Replacement in vitro Catalyzed by a Group I Intron-Derived Ribozyme" Biochemistry 44, 7796-7804.
  
  
• Baum, D. A., Sinha, J., & Testa, S. M. (2005) "Molecular Recognition in a Trans Excision-Splicing Ribozyme: Non-Watson-Crick Base Pairs at the 5' Splice Site and wG at the 3' Splice Site Can Play a Role in Determining the Binding Register of Reaction Substrates" Biochemistry 44, 1067-1077.
  
  
• Johnson, A. K., Baum, D. A., Tye, J., Bell, M. A., & Testa, S. M. (2003) "Molecular Recognition Properties of IGS-Mediated Reactions Catalyzed by a Pneumocystis carinii Group I Intron" Nucleic Acids Res. 31, 1921-1934.
  
  

Prior to enrolling in grad school, I worked at the Genome Sequencing Center at the Washington University School of Medicine in St. Louis, MO. I was a member of one of the production groups, serving as a senior lab technician during my last few months at the Center. The GSC was one of the major centers involved in decoding the sequence of the human genome. Here are the important links to the Nature paper on the sequencing of the Human Genome:

• Full Text HTML Link
• Full Text PDF Link
• Supplementary Material - This contains the full list of authors...I'm with the group from Washington University
  

Last Updated 2/8/2008

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